منابع مشابه
Every little helps
suggested a figure of 60 — that a chart of their activities would be as unappealingly complicated as a chart of intermediary metabolism. His prediction of the number of motor proteins has turned out to be disturbingly accurate (how did he do it?), though the charts have remained appealing. The significance of all this is that there are movements within cells, and motors responsible for them, th...
متن کاملImpact of Education on Weight in Newly Diagnosed Type 2 Diabetes: Every Little Bit Helps
AIMS Highly structured, intensive behavioral lifestyle interventions have been shown to be efficacious in research settings for type 2 diabetes management and weight loss. We sought to evaluate the benefit of participation in more limited counseling and/or education among individuals with newly diagnosed type 2 diabetes in more modest real-world clinical settings. METHODS Electronic Health Re...
متن کاملSelf-confidence and performance: A little self-doubt helps
Objectives: To test the hypothesis that a decrease in confidence on a well-learned task will increase effort and performance. Design: A 2 (group: control, experimental) 2 (trial: practice, competition) mixed-model with repeated measures on the second factor. Method: Expert skippers’ (n 1⁄4 28) self-confidence was reduced via a combination of task (i.e., change of rope) and competitive demands. ...
متن کاملSpeeding protein folding beyond the G(o) model: how a little frustration sometimes helps.
By perturbing a G(o) model toward a realistic protein Hamiltonian by adding non-native interactions, we find that the folding rate is in general enhanced as ruggedness is initially increased, as long as the protein is sufficiently large and flexible. Eventually, the rate drops rapidly toward zero when ruggedness significantly slows conformational transitions. Energy landscape arguments for ther...
متن کاملSingle-molecule studies of RNA polymerase: one singular sensation, every little step it takes.
Transcription is the first of many biochemical steps that turn the genetic information found in DNA into the proteins responsible for driving cellular processes. In this review, we highlight certain advantages of single-molecule techniques in the study of prokaryotic and eukaryotic transcription, and the specific ways in which these techniques complement conventional, ensemble-based biochemistr...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.10.024